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生物标志物发现
生物标志物发现

伴随诊断发现和开发

生物标志物发现

方达是一家经验丰富的RNA测序、转录组分析和免疫分析研究服务提供商,旨在支持临床前样本分析以及已完成临床试验样本的研究。方达已建立且灵活的生物信息管道,以及项目后支持,使研究人员能够识别与特定治疗相关的标记,并满怀信心地向前迈进。

我们的生物标志物发现服务可以缩短伴随诊断和药物疗法的开发时间:

  • 生物流体分析: 方达提供了对生物流体中7个以上生物分子的分析:外显子、mRNA、lncRNA、小RNA、癌症基因、cfDNA甲基化和蛋白质。在可能的情况下进行试点研究,以尽量减少珍贵和有限临床样本的消耗。方达的科学家在处理各种循环、排泄和分泌的生物流体方面经验丰富。
  • 外泌体 RNA 分析:询问外泌体中独特的循环疾病或治疗相关标记,以及组织或细胞特异性外显体RNA标记。
  • RNA测序: 识别影响治疗效果的突变 FFPE 使用 Illumina NextSeq 500、HiSeq 2500 和 HiSeq 4000 仪器的测序。
  • 元转录组学: 通过对各种生物样本的全转录组进行测序,检测与治疗效果相关的微生物及其代谢特征。
  • 微小核糖核酸: 方达通过 Affymetrix 行业标准阵列提供 microRNA 微阵列服务,以及专有阵列和标记/杂交过程,以提供无与伦比的低丰度靶 RNA 分子检测。我们的 microRNA 分析服务经过优化,可支持生物标志物发现计划。
  • 免疫测定: 为各种样品中蛋白质的准确和灵敏定量提供完整服务。定制检测组可用于评估多个疾病区域的1到60种分析物。肿瘤相关分析物包括循环肿瘤、血管生成和转移生物标记物。
  • cfDNA 亚硫酸氢盐测序: 使用组织、基因组DNA(gDNA)或循环无细胞DNA(cfDNA)样本探索疾病或治疗对甲基化模式的影响。
  • 肿瘤检测组: 通过对多达100个已知与癌症相关的基因的蛋白质编码区进行高覆盖率测序,分析液体活检样本。小组检测等位基因频率低至1%的遗传变异,并分析多种变异类型,如种系和体细胞突变、基因融合事件、INDEL、SNP和结构变异。
  • 预测建模: 确定可能与诊断、预后或筛查目的相关的可靠遗传生物标记物。

方达提供的所有服务都得到了项目后咨询以及专利和FDA申请材料、手稿和海报生成的支持。我们的配套诊断服务旨在减少消耗,缩短化合物发现到批准的时间。

样品类型 (可提供特定于平台的分析)

全血 外泌体 粪便 淋巴液 灌洗液
血清 游离DNA 尿 腹水 口腔拭子
血浆 基因组DNA 脑脊液 滑液 干血斑
组织 细胞 FFPE 乳汁 眼泪
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