药物转运体服务

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药物转运体服务

药物转运体服务

在方达，我们在药物转运蛋白研究方面拥有丰富的经验。我们提供全面的转运蛋白服务，以支持从发现到开发的项目，包括筛选以及摄取和流出转运蛋白的全面表征

我们提供创新的解决方案，以更好地了解转运蛋白在药物性肝损伤 (DILI) 中的意义

肝转运蛋白通过从肝细胞中输出胆汁盐和磷脂酰胆碱 (PC) 来帮助促进胆汁的产生。在人体中，抑制胆汁盐输出蛋白（BSEP、ABCB11）和/或多药耐药蛋白 3（MDR3、ABCB4）转运蛋白可导致潜在的严重 DILI。

候选化合物可以被筛选BSEP和/或MDR3的抑制作用，以评估DILI风险。
BSEPcyte® 和 MDR3cyte® 检测分别检测候选药物抑制 BSEP 和 MDR3 的潜力。这两种方法都利用了肝细胞悬浮平台，与其他体外技术相比，它具有以下几个优势：

• 与囊泡和转染细胞系相比，肝细胞的生理相关性更强
• 肝细胞具有原位代谢能力
• 悬浮研究可节省细胞培养时间并加快数据生成
• 分析准确、可靠、可重复且可定制
• 分析允许跨物种比较
• 输出胆汁盐的特定 LC-MS/MS 测定

BSEPcyte®

BSEP负责胆盐的胆汁分泌，
这是胆盐肠肝循环和维持胆汁流量的主要驱动力。
多种药物或治疗药剂对BSEP的抑制与 DILI 相关。
在方达，我们已经开发了全新的分析方案，
BSEPcyte®，能准确地测定对 BSEP的抑制。

BSEPcyte® 受美国专利 9,772,325 保护

MDR3cyte®

MDR3 主要在肝细胞的小管膜中表达，负责 PC（磷脂酰胆碱）的胆汁分泌。 PC 与胆汁盐结合在胆汁中形成混合微胶粒，可溶解胆固醇并防止高度浓缩的胆汁盐损害胆小管上皮细胞。
人类 MDR3 基因的突变与进行性家族性肝内胆汁淤积、原发性胆汁性肝硬化、胆管癌和 DILI 相关。方达新颖的 MDR3cyte® 分析平台可以准确评估候选药物和新化学实体对 MDR3 的抑制作用。

MDR3cyte® 受美国专利 10,280,401 保护

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